2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile
CAS No.:1201645-62-6
Molecular Formula:C₂₂H₂₂N₄O₂
Molecular Weight:374.442
Hs Code.:

Synonyms:2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

There total 1 articles about 2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 109-01-3
1-methyl-piperazine

: 1201643-85-7
2-(4-((6-bromo-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1201645-62-6
2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 1201645-61-5
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 14 ℃; for 15h;

Reference yield: 65.0%

: 1201645-62-6
2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 1201645-66-0
2-(4-((6-(4-dimethylamino)-3-aminoquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; at 25 ℃; under 760.051 Torr;

Reference yield:

: 1201645-62-6
2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 1201645-65-9
2-(4-(8-(dimethylamino)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / nickel / tetrahydrofuran / 25 °C / 760.05 Torr

2: potassium acetate / toluene

3: isopentyl nitrite / toluene / 18 h / 80 °C

4: methanol; potassium carbonate

With methanol; hydrogen; potassium acetate; potassium carbonate; isopentyl nitrite; nickel; In tetrahydrofuran; toluene;