2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Base Information

Chemical Name:2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile
CAS No.:1201645-61-5
Molecular Formula:C₂₅H₂₇N₅O₂
Molecular Weight:429.522
Hs Code.:

Synonyms:2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Suppliers and Price of 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

There total 11 articles about 2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 109-01-3
1-methyl-piperazine

: 1201643-85-7
2-(4-((6-bromo-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1201645-62-6
2-(4-((6-(4-dimethylamino)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile

: 1201645-61-5
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 14 ℃; for 15h;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1201645-61-5
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

4.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

7.1: hydrogenchloride / acetone / 24 h

8.1: hydrogenchloride / water / 24 h

9.1: potassium acetate / ethanol / 5 h / Reflux

10.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 15 h / 14 °C

With hydrogenchloride; triethylsilane; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; sodium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 4-(1-cyano-1-methylethyl)benzoic acid chloride

: 1201645-61-5
2-methyl-2-(4-((6-(4-methylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 15 h / 14 °C

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium acetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; ozone; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;