tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate
CAS No.:1342837-57-3
Molecular Formula:C₃₃H₃₇FN₆O₄S
Molecular Weight:632.759
Hs Code.:

Synonyms:tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1342837-57-3
tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

Guidance literature:: 1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea; (piperidin-4-yl)carbamic acid tert-butyl ester; With acetic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 83.0%

: 1342837-57-3
tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

: 108-24-7
acetic anhydride

: 1342837-59-5
tert-butyl 4-(N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)acetamido)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 55 ℃;

Reference yield:

: 1342837-57-3
tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methylamino)piperidine-1-carboxylate

: 1429340-25-9
N-(1-(2,5.8.11-tetraoxatridecan-13-yl)piperidin-4-yl)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3.2-b]pyridin-2-yl)pyridin-3-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 55 °C

2: hydrogenchloride / ethyl acetate / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With hydrogenchloride; potassium carbonate; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;