(S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

Base Information

Chemical Name:(S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol
CAS No.:1638220-82-2
Molecular Formula:C₁₉H₂₃F₃O
Molecular Weight:324.386
Hs Code.:

Synonyms:(S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

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Chemical Property of (S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

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Technology Process of (S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

There total 16 articles about (S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1638220-75-3
(S,2E,6E)-ethyl 5-methyl-7-(4-(trifluoromethyl)phenyl)-5-vinylhepta-2,6-dienoate

: 917-54-4
methyllithium

: 1638220-82-2
(S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.3390/molecules19022213

Reference yield: 96.0%

: 1638220-82-2
(S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

Guidance literature:: In tetrahydrofuran; Inert atmosphere;

Reference yield:

: C₁₁H₁₇NO₃

: 1638220-82-2
(S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hexamethyldisilazane / 1.5 h / -78 °C / Inert atmosphere

1.2: 6 h / -50 °C

2.1: lithium borohydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 5 h / 20 °C / Inert atmosphere

6.1: toluene / 2 h / Inert atmosphere; Reflux

7.1: hydrogenchloride / ethanol / 7 h / 0 °C / Inert atmosphere

8.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 5 h / 20 °C / Inert atmosphere

9.1: chromium dichloride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

10.1: n-butyllithium; zinc(II) chloride / tetrahydrofuran / 1.25 h / -78 - 20 °C / Inert atmosphere

10.2: 20 °C / Inert atmosphere

11.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; chromium dichloride; hydrogenchloride; lithium borohydride; n-butyllithium; sodium hexamethyldisilazane; diisobutylaluminium hydride; zinc(II) chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene; 6.1: |Wittig Olefination / 9.1: |Takai-Utimoto Olefination;
DOI:10.3390/molecules19022213