Technology Process of 13-benzyl-1-ethenyl-8,13,13b,14-tetrahydroindolo<2',3':3,4>pirido<2,1-b><2,7>naphthyridin-5<7H>-imine
There total 8 articles about 13-benzyl-1-ethenyl-8,13,13b,14-tetrahydroindolo<2',3':3,4>pirido<2,1-b><2,7>naphthyridin-5<7H>-imine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -40 ℃;
for 3h;
DOI:10.1039/c39860001608
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / NaH / benzene / 1.) reflux, 20 min; 2.) 12 h, room temp.
2: 95 percent / H2, / 5percent Rh-Al2O3 / tetrahydrofuran; various solvent(s) / 48 h / 2068.6 Torr
3: 96 percent / 2 h / 120 °C
4: 77 percent / POCl3 / ice bath, room temp. 10-20 min, 40 deg C, 5 min, room temp., 2 h
5: tetrahydrofuran / 1 h / -78 °C
6: 1.) THF, -78 deg C, 20 min, -40 deg C, 4 h
With
hydrogen; sodium hydride; trichlorophosphate;
rhodium on alumina;
In
tetrahydrofuran; benzene;
DOI:10.1016/S0040-4020(01)87781-4
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 78 percent / NaH / benzene / 1.) reflux, 20 min; 2.) 12 h, room temp.
2: 95 percent / H2, / 5percent Rh-Al2O3 / tetrahydrofuran; various solvent(s) / 48 h / 2068.6 Torr
3: 96 percent / 2 h / 120 °C
4: 77 percent / POCl3 / ice bath, room temp. 10-20 min, 40 deg C, 5 min, room temp., 2 h
5: tetrahydrofuran / 1 h / -78 °C
6: 1.) THF, -78 deg C, 20 min, -40 deg C, 4 h
With
hydrogen; sodium hydride; trichlorophosphate;
rhodium on alumina;
In
tetrahydrofuran; benzene;
DOI:10.1016/S0040-4020(01)87781-4
