((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Chemical Name:((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester
CAS No.:124655-11-4
Molecular Formula:C₃₄H₄₀FNO₄
Molecular Weight:545.694
Hs Code.:

Synonyms:((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Chemical Property of ((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Technology Process of ((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

There total 9 articles about ((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 124655-11-4
((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / LDA / tetrahydrofuran / 1.75 h / -70 - -15 °C

2: 1). Et₃B; 2.) NaBH₄, MeOH / 1.) THF, 23 deg C, 15 min; 2.) -70 deg C

3: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C

4: 80 percent / Bu₄NF / tetrahydrofuran / 3 h / 0 °C

5: 97 percent / Swern oxidation; (further oxidizing agents)

6: n-BuLi / tetrahydrofuran / 0 °C / further reaction conditions

With methanol; sodium tetrahydroborate; n-butyllithium; triethyl borane; tetrabutyl ammonium fluoride; lithium diisopropyl amide; toluene-4-sulfonic acid; In tetrahydrofuran; acetone;
DOI:10.1016/0040-4039(90)80121-2

Reference yield:

: 124655-07-8
(3R,5S)-tert-butyl 6-(tert-butyldiphenylsilyloxy)-3,5-dihydroxyhexanoate

: 124655-11-4
((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C

2: 80 percent / Bu₄NF / tetrahydrofuran / 3 h / 0 °C

3: 97 percent / Swern oxidation; (further oxidizing agents)

4: n-BuLi / tetrahydrofuran / 0 °C / further reaction conditions

With n-butyllithium; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; acetone;
DOI:10.1016/0040-4039(90)80121-2

Reference yield:

: 124655-06-7
(5S)-6-(tert-butyl-diphenylsilanyloxy)-5-hydroxy-3-oxohexanoic acid tert-butyl ester

: 124655-11-4
((4R,6S)-6-{(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1). Et₃B; 2.) NaBH₄, MeOH / 1.) THF, 23 deg C, 15 min; 2.) -70 deg C

2: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C

3: 80 percent / Bu₄NF / tetrahydrofuran / 3 h / 0 °C

4: 97 percent / Swern oxidation; (further oxidizing agents)

5: n-BuLi / tetrahydrofuran / 0 °C / further reaction conditions

With methanol; sodium tetrahydroborate; n-butyllithium; triethyl borane; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; acetone;
DOI:10.1016/0040-4039(90)80121-2