ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

Base Information

Chemical Name:ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate
CAS No.:1067649-55-1
Molecular Formula:C₂₂H₁₄Cl₃N₃O₂
Molecular Weight:458.731
Hs Code.:

Synonyms:ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

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Chemical Property of ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

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Technology Process of ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

There total 7 articles about ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067649-58-4
2-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)nicotinamide

: 4755-77-5
Ethyl oxalyl chloride

: 1067649-55-1
ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

Guidance literature:: 2-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)nicotinamide; Ethyl oxalyl chloride; In toluene; at 100 ℃;

With trichlorophosphate; In toluene; at 100 ℃; for 2h;

Reference yield:

: C₂₂H₁₅Cl₂N₃O₃

: 1067649-55-1
ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

Guidance literature:: With trichlorophosphate; at 100 ℃;
DOI:10.1016/j.bmcl.2009.03.005

Reference yield:

: 654668-43-6
1-(2-chlorophenyl)-2-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

: 1067649-55-1
ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / methanol; N,N-dimethyl-formamide; mineral oil / 2.5 h / 95 °C

2.1: trichlorophosphate / 17 h / 100 °C

3.1: ammonium hydroxide / 1,4-dioxane / 100 °C

4.1: sulfuric acid / 2 h / 100 °C

5.1: toluene / 100 °C

5.2: 2 h / 100 °C

With ammonium hydroxide; sulfuric acid; sodium hydride; trichlorophosphate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; mineral oil;