(R)-Bunitrolol

Base Information

• Chemical Name: (R)-Bunitrolol
• CAS No.: 46905-83-3
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.325
• Mol file: 46905-83-3.mol

Synonyms:Benzonitrile,2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-, (R)-; (-)-Bunitrolol; (R)-Bunitrolol

Chemical Property of (R)-Bunitrolol

Chemical Property:

• PSA: 65.28000
• LogP: 2.07698

Purity/Quality:

99%min ^*data from raw suppliers

(R)-BUNITROLOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-Bunitrolol

There total 60 articles about (R)-Bunitrolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(RS)-1-chloro-3-(2-cyanophenoxy)propan-2-ol (42864-99-3) + tert-butylamine (75-64-9) → bunitrolol (34915-68-9,46905-83-3,83073-79-4,59995-59-4)

Guidance literature:

With triethylamine; In ethanol; for 10h;

DOI:10.1055/s-0033-1340465

Reference yield: 92.0%

(R)-1-chloro-3-(2-cyanophenoxy)propan-2-ol + tert-butylamine (75-64-9) → (S)-1-(2-cyanophenoxy)-2-hydroxy-3-tert-butylamino-propane (46905-83-3,83073-79-4,59995-59-4)

Guidance literature:

With triethylamine; In ethanol; for 10h; Reflux;

DOI:10.1055/s-0033-1340465

Reference yield: 91.0%

(R)-1-chloro-3-(2-cyanophenoxy)propan-2-ol + tert-butylamine (75-64-9) → (R)-1-(2-cyanophenoxy)-2-hydroxy-3-tert-butylamino-propane (46905-83-3,83073-79-4,59995-59-4)

Guidance literature:

With triethylamine; In ethanol; for 10h; Reflux;

DOI:10.1055/s-0033-1340465

upstream raw materials:

1,2-epoxy-3-(2-cyanophenyl)propane

salicylonitrile

(RS)-1-chloro-3-(2-cyanophenoxy)propan-2-ol

tert-butylamine

Refernces

• 1、 Gogaladze, Khatuna,Chankvetadze, Lali,Tsintsadze, Maia,Farkas, Tivadar,Chankvetadze, Bezhan. "Effect of basic and acidic additives on the separation of some basic drug enantiomers on polysaccharide-based chiral columns with acetonitrile as mobile phase". . p. 228 - 234. Retrieved 2015/03/18.
• 2、 -. "THERAPY FOR COMPLICATIONS OF DIABETES". . . Retrieved 2009/07/02.