N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide
• CAS No.: 202532-13-6
• Molecular Formula: C₄₂H₆₇N₃O₄S₃Si₂
• Molecular Weight: 830.381
• Mol file: 202532-13-6.mol

Synonyms:N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide

Chemical Property of N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide

There total 11 articles about N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide (202532-13-6)

Guidance literature:

Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

2: 81 percent / acetonitrile / 50 h / Heating

3: 87 percent / NaH / paraffin; tetrahydrofuran / Ambient temperature

4: 100 percent / methanol; CH₂Cl₂ / 1 h / Ambient temperature

5: 65 percent / LiAlH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

6: 79 percent / imidazole / acetonitrile / 2 h / Ambient temperature

7: acetonitrile / 35 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; paraffin;

Reference yield:

2-[(2S)-5-oxopyrrolidin-2-yl]acetonitrile (72479-06-2,98134-78-2) → N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide (202532-13-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / NaH / paraffin; tetrahydrofuran / Ambient temperature

2: 100 percent / methanol; CH₂Cl₂ / 1 h / Ambient temperature

3: 65 percent / LiAlH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

4: 79 percent / imidazole / acetonitrile / 2 h / Ambient temperature

5: acetonitrile / 35 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; paraffin;

Reference yield:

(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester (51693-17-5) → N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide (202532-13-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 81 percent / acetonitrile / 50 h / Heating

2: 87 percent / NaH / paraffin; tetrahydrofuran / Ambient temperature

3: 100 percent / methanol; CH₂Cl₂ / 1 h / Ambient temperature

4: 65 percent / LiAlH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

5: 79 percent / imidazole / acetonitrile / 2 h / Ambient temperature

6: acetonitrile / 35 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; paraffin;

upstream raw materials:

N-[(S)-1-(2-Amino-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide

tert-Butyl-((S)-3-isothiocyanato-5-methylsulfanyl-pentyloxy)-dimethyl-silane

2-[(2S)-5-oxopyrrolidin-2-yl]acetonitrile

(S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester