Technology Process of (2R,3R,4R,5R,6S)-3-Benzyloxy-2-methoxy-6-methyl-5-((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-ol
There total 10 articles about (2R,3R,4R,5R,6S)-3-Benzyloxy-2-methoxy-6-methyl-5-((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-ol which
guide to synthetic route it.
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synthetic route:
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182804-42-8
(2R,3R,4R,5R,6S)-3-Benzyloxy-2-methoxy-6-methyl-5-((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-ol
- Guidance literature:
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With
90percent aq. CFCOOH;
In
chloroform;
at 20 ℃;
for 0.0833333h;
Yield given;
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182804-42-8
(2R,3R,4R,5R,6S)-3-Benzyloxy-2-methoxy-6-methyl-5-((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-ol
- Guidance literature:
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Multi-step reaction with 8 steps
1: Hg(CN)2, HgBr2, molecular sieves 4 Angstroem / acetonitrile / 1 h
2: 90percent aq. CF3COOH / 1 h
3: TsOH / H2O; dimethylformamide / 3 h / Ambient temperature
4: 90percent aq. acetic acid / dimethylformamide / 1 h
5: 2,4,6-collidine / CH2Cl2 / 6 h / 20 °C
6: sodium methylate, methanol / 20 h / 20 °C
7: KOH / dimethylsulfoxide / 20 h / 20 °C
8: 90percent aq. CFCOOH / CHCl3 / 0.08 h / 20 °C
With
2,4,6-trimethyl-pyridine; methanol; potassium hydroxide; 4 A molecular sieve; sodium methylate; mercury(II) cyanide; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; mercury dibromide;
In
dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
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182804-42-8
(2R,3R,4R,5R,6S)-3-Benzyloxy-2-methoxy-6-methyl-5-((2R,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-ol
- Guidance literature:
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Multi-step reaction with 2 steps
1: KOH / dimethylsulfoxide / 20 h / 20 °C
2: 90percent aq. CFCOOH / CHCl3 / 0.08 h / 20 °C
With
potassium hydroxide;
In
chloroform; dimethyl sulfoxide;