N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

Base Information

Chemical Name:N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide
CAS No.:1472104-54-3
Molecular Formula:C₂₁H₂₂ClFN₂O₂
Molecular Weight:388.869
Hs Code.:

Synonyms:N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

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Chemical Property of N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

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Technology Process of N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

There total 9 articles about N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: trifluoromethanesulfonic acid [2-[(4-chlorophenyl)methylcarbamoyl]-3-fluoro-5-morpholin-4-ylphenyl] ester

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1472104-54-3
N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In N,N-dimethyl-formamide; at 120 ℃; for 16.5h; Inert atmosphere;

Reference yield: 30.0%

: trifluoro-methanesulfonic acid [2-[(4-chlorophenyl)-methyl-carbamoyl]-3-fluoro-5-morpholin-4-yl-phenyl]ester

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1472104-54-3
N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

Guidance literature:: trifluoro-methanesulfonic acid [2-[(4-chlorophenyl)-methyl-carbamoyl]-3-fluoro-5-morpholin-4-yl-phenyl]ester; 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; With potassium phosphate; In N,N-dimethyl-formamide; Inert atmosphere;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 120 ℃; for 16h;

Reference yield:

: 1472104-49-6
4-bromo-2-fluoro-6-methoxy-benzoic acid

: 1472104-54-3
N-[(4-chlorophenyl)-methyl]-2-fluoro-6-isopropenyl-4-morpholin-4-yl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 °C

1.2: 16 h / 0 - 23 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 16.75 h / 120 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 2 h / -78 - 23 °C

3.2: Cooling

4.1: caesium carbonate / dichloromethane; acetonitrile / 4 h / 23 °C

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 16.5 h / 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxalyl dichloride; boron tribromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N,N-dimethyl-formamide; sodium t-butanolate; In dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;