4-broMo-2-fluoro-6-Methoxybenzaldehyde

Base Information

• Chemical Name: 4-broMo-2-fluoro-6-Methoxybenzaldehyde
• CAS No.: 856767-09-4
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.037
• Hs Code.: 2913000090
• Mol file: 856767-09-4.mol

Synonyms:4-broMo-2-fluoro-6-Methoxybenzaldehyde;Benzaldehyde, 4-broMo-2-fluoro-6-Methoxy-

Chemical Property of 4-broMo-2-fluoro-6-Methoxybenzaldehyde

Chemical Property:

• Boiling Point: 270.8±40.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.601±0.06 g/cm3(Predicted)
• LogP: 2.40930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-fluoro-6-methoxybenzaldehyde >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2-fluoro-6-methoxybenzaldehyde is used in preparation of dihydropyrimidines as Brd9 bifunctional degraders for treatment and prophylaxis of Brd9-mediated diseases.

Technology Process of 4-broMo-2-fluoro-6-Methoxybenzaldehyde

There total 9 articles about 4-broMo-2-fluoro-6-Methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-bromo-2,6-difluorobenzaldehyde (537013-51-7) + sodium methylate (124-41-4) → 4-bromo-2-fluoro-6-methoxy-benzaldehyde (856767-09-4)

Guidance literature:

In methanol; for 25h; Time; Reflux;

Reference yield: 91.0%

methanol (67-56-1) + 4-bromo-2,6-difluorobenzaldehyde (537013-51-7) + sodium methylate (124-41-4) → 4-bromo-2-fluoro-6-methoxy-benzaldehyde (856767-09-4)

Guidance literature:

for 25h; Reflux;

DOI:10.1021/acs.jmedchem.8b01837

Reference yield: 60.0%

1-bromo-3-fluoro-5-methoxybenzene (29578-39-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2-fluoro-6-methoxy-benzaldehyde (856767-09-4) + 2-bromo-6-fluoro-4-methoxybenzaldehyde

Guidance literature:

1-bromo-3-fluoro-5-methoxybenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at -70 ℃;

DOI:10.1016/j.tetlet.2005.04.065

upstream raw materials:

1-bromo-3-fluoro-5-methoxybenzene

N,N-dimethyl-formamide

4-bromo-2-fluoro-6-methoxy-benzonitrile

methanol

Downstream raw materials:

6-bromo-4-methoxy-1H-indazole

methyl 4-methoxy-1H-indazole-6-carboxylate

methyl 4-methoxy-2-methyl-2H-indazole-6-carboxylate

methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate