(3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

Base Information

Chemical Name:(3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile
CAS No.:370593-06-9
Molecular Formula:C₃₆H₄₁NO₄Si
Molecular Weight:579.811
Hs Code.:

Synonyms:(3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

Suppliers and Price of (3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

There total 4 articles about (3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153096-83-4
(3R,4S)-4,5-Bis-benzyloxy-3-(tert-butyl-diphenyl-silanyloxymethyl)-pent-1-en-3-ol

: 370593-06-9
(3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone / CH₂Cl₂ / 0.75 h / -78 °C

1.2: NaBH₄ / CH₂Cl₂; ethanol / 2 h / 20 °C

2.1: triethylamine; DMAP / CH₂Cl₂ / 7 h / -30 - 0 °C

3.1: 348 mg / dimethylsulfoxide / 18 h / 55 °C

With dmap; ozone; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(01)00262-2

Reference yield:

: (2R,3S)-3,4-Bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-butane-1,2-diol

: 370593-06-9
(3R,4S)-4,5-bis(benzyloxy)-3(tert-butyldiphenylsilyloxymethyl)-3-hydroxypentanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; DMAP / CH₂Cl₂ / 7 h / -30 - 0 °C

2: 348 mg / dimethylsulfoxide / 18 h / 55 °C

With dmap; triethylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(01)00262-2