N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide

Base Information

• Chemical Name: N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide
• CAS No.: 1417860-71-9
• Molecular Formula: C₁₈H₁₇Cl₂NO₄
• Molecular Weight: 382.243
• Mol file: 1417860-71-9.mol

Synonyms:N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide

Chemical Property of N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide

There total 3 articles about N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

1,3-benzodioxol-5-ylmethyl amine (2620-50-0) + 2-(2,4-dichlorophenoxy)butanoic acid (6956-86-1) → N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide (1417860-71-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2015.01.011

Reference yield:

2,4-dichlorophenol (120-83-2,40477-79-0) → N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide (1417860-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: sodium hydroxide; water / ethanol / 4 h / Reflux

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.01.011

Reference yield:

(+/-)-2-(2,4-dichloro-phenoxy)-butyric acid ethyl ester (10463-04-4) → N-[3,4-(methylenedioxy)benzyl]-2-(2,4-dichlorophenoxy)butanamide (1417860-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 4 h / Reflux

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2015.01.011

upstream raw materials:

2,4-dichlorophenol

(+/-)-2-(2,4-dichloro-phenoxy)-butyric acid ethyl ester

1,3-benzodioxol-5-ylmethyl amine

2-(2,4-dichlorophenoxy)butanoic acid