7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

Base Information

Chemical Name:7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione
CAS No.:157402-73-8
Molecular Formula:C₂₄H₂₅FN₆O₃
Molecular Weight:464.499
Hs Code.:

Synonyms:7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

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Chemical Property of 7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

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Technology Process of 7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

There total 7 articles about 7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 109-01-3
1-methyl-piperazine

: 157402-72-7
7-(benzyloxy)-2-chloro-10-cyclopropyl-3-fluoro-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

: 157402-73-8
7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

Guidance literature:: With potassium iodide; In various solvent(s); at 120 ℃; for 12h;
DOI:10.1002/hlca.19940770419

Reference yield:

: 29512-07-0
N-cyclopropylacetamide

: 157402-73-8
7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, 3.) K₂CO₃ / 1.) Et₂O, r.t., 6 h; 2.) Et₂O, 24 deg C, 16 h, 0 deg C, 1 h; 3.) DMF, 155-160 deg C, 48 h

2: 1.) LiN(Me₃Si)2 / 1.) -75 deg C, THF, 2 h; 2.) -75 deg C, 2 h, THF

3: 95 percent / NaCN, NH₃ / methanol / 1 h / 45 - 50 °C / 1.) 45-50 deg C, 1 h, 24 deg C, 95percent

4: 69 percent / ethanol; H₂O / 48 h / 73 °C

5: 85 percent / tetrahydrofuran / 1 h / 65 - 70 °C

6: 76 percent / KI / various solvent(s) / 12 h / 120 °C

With oxalyl dichloride; sodium cyanide; ammonia; potassium carbonate; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/hlca.19940770419

Reference yield:

: 152840-65-8
2,6-dichloro-5-fluoropyridine-3-amine

: 157402-73-8
7-(benzyloxy)-10-cyclopropyl-3-fluoro-2-(4-methylpiperazin-1-yl)-6,7,8,10-tetrahydropyrido<2',3':4,5>imidazo<1,2-c>pyrimidine-6,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, 3.) K₂CO₃ / 1.) Et₂O, r.t., 6 h; 2.) Et₂O, 24 deg C, 16 h, 0 deg C, 1 h; 3.) DMF, 155-160 deg C, 48 h

2: 1.) LiN(Me₃Si)2 / 1.) -75 deg C, THF, 2 h; 2.) -75 deg C, 2 h, THF

3: 95 percent / NaCN, NH₃ / methanol / 1 h / 45 - 50 °C / 1.) 45-50 deg C, 1 h, 24 deg C, 95percent

4: 69 percent / ethanol; H₂O / 48 h / 73 °C

5: 85 percent / tetrahydrofuran / 1 h / 65 - 70 °C

6: 76 percent / KI / various solvent(s) / 12 h / 120 °C

With oxalyl dichloride; sodium cyanide; ammonia; potassium carbonate; potassium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1002/hlca.19940770419