6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

Base Information

Chemical Name:6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide
CAS No.:1227866-29-6
Molecular Formula:C₂₀H₁₅F₂N₅O
Molecular Weight:379.369
Hs Code.:

Synonyms:6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

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Technology Process of 6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

There total 2 articles about 6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1227863-02-6
6-[(2-aminophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

: 149-73-5
trimethyl orthoformate

: 1227866-29-6
6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

Guidance literature:: toluene-4-sulfonic acid; In methanol; at 20 ℃; for 4h;

Reference yield:

: 1227487-15-1
6-chloro-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

: 95-54-5
1,2-diamino-benzene

: 1227866-29-6
6-(1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonic acid / diphenylether / 0.5 h / 180 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 4 h / 20 °C

With methanesulfonic acid; toluene-4-sulfonic acid; In methanol; diphenylether;