(E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate
CAS No.:1427690-54-7
Molecular Formula:C₂₇H₃₁F₃O₂
Molecular Weight:444.537
Hs Code.:

Synonyms:(E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

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Chemical Property of (E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

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Technology Process of (E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

There total 4 articles about (E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1427690-53-6
(E)-ethyl 3-(3-bromo-4-(trifluoromethyl)phenyl)acrylate

: 169126-64-1
(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-boronic acid

: 1427690-54-7
(E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

Guidance literature:: With tetrabutylammomium bromide; palladium diacetate; sodium carbonate; In water; at 20 - 150 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 6683-48-3
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

: 1427690-54-7
(E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / chloroform / 0.5 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 3.33 h / -78 - 20 °C / Inert atmosphere

2.3: 2 h

3.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / water / 0.33 h / 20 - 150 °C / Inert atmosphere

With n-butyllithium; tetrabutylammomium bromide; bromine; palladium diacetate; sodium carbonate; In tetrahydrofuran; hexane; chloroform; water;

Reference yield:

: 372120-55-3
3-bromo-4-(trifluoromethyl)benzaldehyde

: 1427690-54-7
(E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.5 h / -30 °C

1.2: 1.5 h / -30 °C

2.1: tetrabutylammomium bromide; sodium carbonate; palladium diacetate / water / 0.33 h / 20 - 150 °C / Inert atmosphere

With tetrabutylammomium bromide; palladium diacetate; sodium hydride; sodium carbonate; In 1,2-dimethoxyethane; water; mineral oil;