372120-55-3

Basic information

• Product Name: 3-broMo-4-trifluoroMethylbenzaldehyde
• Synonyms: 3-broMo-4-trifluoroMethylbenzaldehyde;2-Bromo-4-formylbenzotrifluoride, 3-Bromo-alpha,alpha,alpha-trifluoro-p-tolualdehyde
• CAS NO: 372120-55-3
• Molecular Formula: C₈H₄BrF₃O
• Molecular Weight: 253.0159696
• Mol File: 372120-55-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 244.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.677±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-broMo-4-trifluoroMethylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-broMo-4-trifluoroMethylbenzaldehyde(372120-55-3)
• EPA Substance Registry System: 3-broMo-4-trifluoroMethylbenzaldehyde(372120-55-3)

Safety Data

• Hazardous Substances Data: 372120-55-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-trifluoromethylbenzaldehyde is a chemical compound with the molecular formula C8H4BrF3O. It is a white to light yellow crystalline solid that is commonly used as a building block in organic synthesis. 3-Bromo-4-trifluoromethylbenzaldehyde is often employed in the pharmaceutical and agrochemical industries for the production of various intermediates and active ingredients. It is also used in research and development for the synthesis of new chemical entities. Additionally, 3-Bromo-4-trifluoromethylbenzaldehyde has been studied for its potential biological and pharmacological properties, making it a versatile and valuable chemical in a range of applications.

Upstream product

• 372120-54-2 3-bromo-4-trifluoromethylphenyl methanol 
• 372119-86-3 [3-nitro-4-(trifluoromethyl)phenyl]methanol 
• 116965-16-3 3-nitro-4-(trifluoromethyl)benzoic acid 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 372120-51-9 [3-amino-4-(trifluoromethyl)phenyl]methanol 

Downstream Products

• 1427690-52-5 (E)-3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)phenyl)acrylic acid 

Relevant articles and documents

Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinoline-8(4H)-one 1,1-dioxide K ATP channel openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b] quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent KATP opener that selectively inhibits spontaneous bladder contractions

Structure-activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry, and aromatic substitution were evaluated for K ATP activity in guinea pig bladder cells using a fluorescence-based membrane potential assay and in a pig bladder strip assay. The inhibition of spontaneous bladder contractions in vitro was also examined for a select group of compounds. All compounds studied showed greater potency to inhibit spontaneous bladder contractions relative to their potencies to inhibit contractions elicited by electrical stimulation. In an anesthetized pig model of myogenic bladder overactivity, compound 14 and (-)-cromakalim 1 were found to inhibit spontaneous bladder contractions in vivo at plasma concentrations lower than those that affected hemodynamic parameters. Compound 14 showed approximately 5-fold greater selectivity than 1 in vivo and supports the concept that bladder-selective KATP channel openers may have utility in the treatment of overactive bladder.

Process for the preparation of fluorine containing benzaldehydes

Fluor enthaltende Benzaldehyde werden in besonders vorteilhafter Weise erhalten, wenn man ein entsprechendes aromatisches S?urechlorid mit Wasserstoff in Gegenwart eines getr?gerten Palladium-Katalysators und eines Katalysator-Moderators umsetzt.