372120-55-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4-trifluoromethylbenzaldehyde is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it an indispensable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-4-trifluoromethylbenzaldehyde is employed for the production of active ingredients in pesticides and other crop protection agents. Its chemical properties enable the creation of effective and targeted agrochemicals that contribute to enhanced crop yields and protection against pests.
Used in Research and Development:
3-Bromo-4-trifluoromethylbenzaldehyde is also used in research and development settings for the synthesis of new chemical entities. Its reactivity and structural features make it a valuable precursor in the exploration of novel chemical compounds with potential applications in various fields.
Used in Biological and Pharmacological Studies:
Furthermore, 3-Bromo-4-trifluoromethylbenzaldehyde has been studied for its potential biological and pharmacological properties. Its unique structure may offer insights into new mechanisms of action or therapeutic targets, contributing to the advancement of medical and biological research.

Upstream product

• 372120-54-2 3-bromo-4-trifluoromethylphenyl methanol 
• 372119-86-3 [3-nitro-4-(trifluoromethyl)phenyl]methanol 
• 116965-16-3 3-nitro-4-(trifluoromethyl)benzoic acid 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 372120-51-9 [3-amino-4-(trifluoromethyl)phenyl]methanol 

Downstream Products

• 1427690-53-6 (E)-ethyl 3-(3-bromo-4-(trifluoromethyl)phenyl)acrylate 
• 1427690-54-7 (E)-ethyl 3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthaIen-7-yI)phenyl)acrylate 
• 1427690-52-5 (E)-3-(4-(trifluoromethyl)-3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)phenyl)acrylic acid 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinoline-8(4H)-one 1,1-dioxide K ATP channel openers: Discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b] quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent KATP opener that selectively inhibits spontaneous bladder contractions

Structure-activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing KATP openers. Ring sizes, absolute stereochemistry, and aromatic substitution were evaluated for K ATP activity in guinea pig bladder cells using a fluorescence-based membrane potential assay and in a pig bladder strip assay. The inhibition of spontaneous bladder contractions in vitro was also examined for a select group of compounds. All compounds studied showed greater potency to inhibit spontaneous bladder contractions relative to their potencies to inhibit contractions elicited by electrical stimulation. In an anesthetized pig model of myogenic bladder overactivity, compound 14 and (-)-cromakalim 1 were found to inhibit spontaneous bladder contractions in vivo at plasma concentrations lower than those that affected hemodynamic parameters. Compound 14 showed approximately 5-fold greater selectivity than 1 in vivo and supports the concept that bladder-selective KATP channel openers may have utility in the treatment of overactive bladder.

Pyrano, piperidino, and thiopyrano compounds and methods of use

The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.

Process for the preparation of fluorine containing benzaldehydes

Fluor enthaltende Benzaldehyde werden in besonders vorteilhafter Weise erhalten, wenn man ein entsprechendes aromatisches S?urechlorid mit Wasserstoff in Gegenwart eines getr?gerten Palladium-Katalysators und eines Katalysator-Moderators umsetzt.