N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine

Base Information

• Chemical Name: N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine
• CAS No.: 1269759-78-5
• Molecular Formula: C₂₅H₃₃N₅O₉
• Molecular Weight: 547.565
• Mol file: 1269759-78-5.mol

Synonyms:N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine

Chemical Property of N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine

There total 7 articles about N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester (1269759-76-3) → N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine (1269759-78-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; for 0.5h;

DOI:10.1039/c0cc03988h

Reference yield:

3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine (65710-57-8,81306-93-6) → N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine (1269759-78-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8.25 h / 20 °C / Cooling with ice

2.1: dichloromethane / 1 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / methanol / 0.5 h / 0 °C

3.2: 3 h / 0 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 65 °C / Inert atmosphere

5.2: 8 h / Cooling with ice

6.1: lithium hydroxide / tetrahydrofuran; methanol; water / 0.5 h

With potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1039/c0cc03988h

Reference yield:

N-(2-Boc-aminoethyl)-N-(chloroacetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester (1269759-74-1) → N-(2-Boc-aminoethyl)-N-(thymine-1-ylacetyl)-N-(3-Cbz-amino)-L-alanine (1269759-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 65 °C / Inert atmosphere

1.2: 8 h / Cooling with ice

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 0.5 h

With potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1039/c0cc03988h

upstream raw materials:

N-(2-Boc-aminoethyl)-N-(chloroacetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

N-(2-Boc-aminoethyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine