N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

Base Information

Chemical Name:N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester
CAS No.:1269759-76-3
Molecular Formula:C₂₆H₃₅N₅O₉
Molecular Weight:561.592
Hs Code.:

Synonyms:N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

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Chemical Property of N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

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Technology Process of N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

There total 6 articles about N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1269759-74-1
N-(2-Boc-aminoethyl)-N-(chloroacetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

: 65-71-4,28806-14-6,691841-57-3
thymin

: 1269759-76-3
N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

Guidance literature:: thymin; With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 1.5h; Inert atmosphere;

N-(2-Boc-aminoethyl)-N-(chloroacetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester; In N,N-dimethyl-formamide; for 8h; Cooling with ice;
DOI:10.1039/c0cc03988h

Reference yield:

: 65710-57-8,81306-93-6
3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine

: 1269759-76-3
N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8.25 h / 20 °C / Cooling with ice

2.1: dichloromethane / 1 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / methanol / 0.5 h / 0 °C

3.2: 3 h / 0 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 65 °C / Inert atmosphere

5.2: 8 h / Cooling with ice

With potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0cc03988h

Reference yield:

: 1269759-72-9
N-(2-Boc-aminoethyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

: 1269759-76-3
N-(2-Boc-aminoethyl)-N-(thymine-1-acetyl)-N-(3-Cbz-amino-L-alanyl)methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 65 °C / Inert atmosphere

2.2: 8 h / Cooling with ice

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0cc03988h