Technology Process of 4-(6-chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid
There total 8 articles about 4-(6-chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
for 16h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale
1.2: 20 °C / Industry scale
2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale
2.2: 1 h / 20 °C / Industry scale
3.1: sodium hydroxide / water / Industry scale
3.2: pH 2 - 3 / Industry scale
3.3: 16 h / Reflux
4.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere
5.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C
With
hydrogenchloride; tin(II) chloride dihdyrate; water; iodine; N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride; sodium hydroxide;
In
1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / water / 10 - 20 °C / Industry scale
1.2: 1 h / 5 - 20 °C
2.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale
2.2: 20 °C / Industry scale
3.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale
3.2: 1 h / 20 °C / Industry scale
4.1: sodium hydroxide / water / Industry scale
4.2: pH 2 - 3 / Industry scale
4.3: 16 h / Reflux
5.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere
6.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C
With
hydrogenchloride; tin(II) chloride dihdyrate; water; iodine; N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride; sodium hydroxide;
In
1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate;
