ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

Base Information

Chemical Name:ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate
CAS No.:1202890-37-6
Molecular Formula:C₂₇H₂₄Cl₃NO₅
Molecular Weight:548.85
Hs Code.:

Synonyms:ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

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Chemical Property of ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

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Technology Process of ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

There total 10 articles about ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1202889-55-1
4-(6-chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid

: 52516-13-9
2-(2,4-dichloro-phenyl)-ethylamine

: 1202890-37-6
ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

Guidance literature:: 4-(6-chloro-4-(ethoxycarbonyl)chroman-7-yloxy)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 5 - 20 ℃; for 20.3333h;

2-(2,4-dichloro-phenyl)-ethylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3.66667h;

Reference yield:

: 74277-66-0
6-chloro-7-hydroxychroman-4-one

: 1202890-37-6
ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

1.2: 20 °C / Industry scale

2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

2.2: 1 h / 20 °C / Industry scale

3.1: sodium hydroxide / water / Industry scale

3.2: pH 2 - 3 / Industry scale

3.3: 16 h / Reflux

4.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20.33 h / 5 - 20 °C

6.2: 3.67 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; tin(II) chloride dihdyrate; water; iodine; N,N-dimethylglycine hydrochoride; caesium carbonate; N,N-dimethyl-formamide; copper(l) chloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate;

Reference yield:

: 1202889-57-3
6-chloro-4,7-bis(trimethylsilyloxy)chroman-4-carbonitrile

: 1202890-37-6
ethyl 6-chloro-7-(4-(2,4-dichlorophenethylcarbamoyl)-phenoxy)chroman-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

1.2: 1 h / 20 °C / Industry scale

2.1: sodium hydroxide / water / Industry scale

2.2: pH 2 - 3 / Industry scale

2.3: 16 h / Reflux

3.1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) chloride / 1,4-dioxane / 20 h / 95 - 97 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20.33 h / 5 - 20 °C

5.2: 3.67 h / 0 - 20 °C

With hydrogenchloride; oxalyl dichloride; tin(II) chloride dihdyrate; water; N,N-dimethylglycine hydrochoride; caesium carbonate; N,N-dimethyl-formamide; copper(l) chloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; acetic acid; ethyl acetate;