4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

Base Information

Chemical Name:4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide
CAS No.:146349-36-2
Molecular Formula:C₁₈H₂₂N₄O₆
Molecular Weight:390.396
Hs Code.:

Synonyms:4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

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Chemical Property of 4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

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Technology Process of 4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

There total 3 articles about 4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.8%

: 683-57-8
bromo-acetic acid amide

: 146349-35-1
4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidine

: 146349-36-2
4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; for 20h; Ambient temperature;
DOI:10.1021/jm00054a010

Reference yield:

: 105414-01-5,102988-94-3
Cbz-L-Pro-OCO₂-i-Bu

: 146349-36-2
4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; CH₂Cl₂ / a) -25 deg C, 30 min, b) RT, 15 h

2: 63.8 percent / Et₃N / tetrahydrofuran / 20 h / Ambient temperature

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00054a010

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 146349-36-2
4(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-3-oxo-2-isoxazolidineacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine / tetrahydrofuran; CCl₄ / 0.33 h / -20 °C

2: tetrahydrofuran; CH₂Cl₂ / a) -25 deg C, 30 min, b) RT, 15 h

3: 63.8 percent / Et₃N / tetrahydrofuran / 20 h / Ambient temperature

With 4-methyl-morpholine; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jm00054a010