(4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone

Base Information

• Chemical Name: (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone
• CAS No.: 117810-92-1
• Molecular Formula: C₂₆H₂₃ClN₂O
• Molecular Weight: 414.934
• Mol file: 117810-92-1.mol

Synonyms:(4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone

Chemical Property of (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone

There total 6 articles about (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

descarboethoxyloratadine (100643-71-8) + benzoyl chloride (98-88-4) → (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone (117810-92-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.1002/anie.202104359

Reference yield: 72.0%

descarboethoxyloratadine (100643-71-8) + benzoic acid (65-85-0,8013-63-6) → (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone (117810-92-1)

Guidance literature:

With dichloro(dimethylglyoxime)(dimethylglyoximato)cobalt(III); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202112668

Reference yield:

N-tert-butyl-3-methylpyridine-2-carboxamide (32998-95-1) → (4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)(phenyl)methanone (117810-92-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, -40 deg C

2: POCl₃ / Heating

3: 2.) aq. HCl / 1.) THF, reflux

4: CF₃SO₃H / Heating

5: Et₃N / toluene / Heating

6: aq. KOH / Heating

7: C₅H₅N / CH₂Cl₂

With pyridine; hydrogenchloride; potassium hydroxide; n-butyllithium; trifluorormethanesulfonic acid; triethylamine; trichlorophosphate; In dichloromethane; toluene;

DOI:10.1021/jm00105a069

upstream raw materials:

descarboethoxyloratadine

benzoyl chloride

N-tert-butyl-3-methylpyridine-2-carboxamide

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide