N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Base Information

Chemical Name:N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid
CAS No.:139348-91-7
Molecular Formula:C₁₉H₂₀N₆O₇
Molecular Weight:444.404
Hs Code.:

Synonyms:N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Suppliers and Price of N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

There total 7 articles about N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-{4-[3-(3-Amino-5-oxo-2,5-dihydro-[1,2,4]triazin-6-yl)-2-oxo-pyrrolidin-1-yl]-benzoylamino}-pentanedioic acid diethyl ester

: 139348-91-7
N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 50 ℃; for 19h;
DOI:10.1021/jm00086a008

Reference yield:

: 139348-98-4
ethyl 4-(4-chlorobutyrylamino)benzoate

: 139348-91-7
N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / t-BuOK / tetrahydrofuran / Ambient temperature

2: 59 percent / NaH / tetrahydrofuran / 2 h / Ambient temperature

3: 96 percent / ethanol; H₂O / 8 h / Heating

4: 56 percent / 1 N aq. NaOH / 1.) RT, 17 h, 2.) 75 deg C, 2 h

5: 1.) N-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC), 2.) N-methylmorpholine / 1.) CH₂Cl₂, DMF, 1 h, 2.) CH₂Cl₂, DMF, 76 h

6: 1 N aq. NaOH / ethanol / 19 h / 50 °C

With 4-methyl-morpholine; sodium hydroxide; potassium tert-butylate; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00086a008

Reference yield:

: 86364-65-0
ethyl <2-oxo-1-pyrrolidinyl>benzoate

: 139348-91-7
N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 59 percent / NaH / tetrahydrofuran / 2 h / Ambient temperature

2: 96 percent / ethanol; H₂O / 8 h / Heating

3: 56 percent / 1 N aq. NaOH / 1.) RT, 17 h, 2.) 75 deg C, 2 h

4: 1.) N-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC), 2.) N-methylmorpholine / 1.) CH₂Cl₂, DMF, 1 h, 2.) CH₂Cl₂, DMF, 76 h

5: 1 N aq. NaOH / ethanol / 19 h / 50 °C

With 4-methyl-morpholine; sodium hydroxide; sodium hydride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00086a008