ethyl 4-[(4-chlorobutanoyl)amino]benzoate

Base Information

• Chemical Name: ethyl 4-[(4-chlorobutanoyl)amino]benzoate
• CAS No.: 139348-98-4
• Molecular Formula: C13H16ClNO3
• Molecular Weight: 269.728
• Hs Code.: 2922390090
• Mol file: 139348-98-4.mol

Synonyms:4-(4-chloro-butyrylamino)-benzoic acid ethyl ester;4-(4-Chlor-butyrylamino)-benzoesaeure-aethylester;

Chemical Property of ethyl 4-[(4-chlorobutanoyl)amino]benzoate

Chemical Property:

• PSA: 55.40000
• LogP: 2.89380

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 4-[(4-chlorobutanoyl)amino]benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-[(4-chlorobutanoyl)amino]benzoate

There total 2 articles about ethyl 4-[(4-chlorobutanoyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

p-aminoethylbenzoate (94-09-7) + 4-Chlorobutanoyl chloride (4635-59-0) → ethyl 4-(4-chlorobutyrylamino)benzoate (139348-98-4)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00086a008

Reference yield:

→ ethyl 4-(4-chlorobutyrylamino)benzoate (139348-98-4)

Guidance literature:

/BRN= 3339444/;

DOI:10.1021/ja01578a061

Reference yield: 83.6%

ethyl 4-(4-chlorobutyrylamino)benzoate (139348-98-4) → ethyl <2-oxo-1-pyrrolidinyl>benzoate (86364-65-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1.33333h; Cooling with ice;

upstream raw materials:

p-aminoethylbenzoate

4-Chlorobutanoyl chloride

Downstream raw materials:

ethyl <2-oxo-1-pyrrolidinyl>benzoate

ethyl 4-<3-(2-ethoxy-1-hydroxy-2-oxoethylidene)-2-oxo-1-pyrrolidinyl>benzoate

4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoic acid

ethyl 4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoate