(4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole
• CAS No.: 1354693-85-8
• Molecular Formula: C₃₁H₂₆FN₅
• Molecular Weight: 487.579
• Mol file: 1354693-85-8.mol

Synonyms:(4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole

Chemical Property of (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole

There total 4 articles about (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(4R,5R)-2-(2-fluorophenyl)-4,5-diphenyl-1-(prop-2-yn-1-yl)-4,5-dihydro-1H-imidazole (1354693-83-6) + benzyl bromide (100-39-0) → (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole (1354693-85-8)

Guidance literature:

With sodium azide; copper(II) sulfate; ascorbic acid; In water; tert-butyl alcohol; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201100684

Reference yield:

(4R,5R)-2-(2-fluoro-phenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazole (503111-12-4) → (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole (1354693-85-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 48 h / 0 - 20 °C / Inert atmosphere

2.1: sodium azide; copper(II) sulfate; ascorbic acid / water; tert-butyl alcohol / 12 h / 40 °C / Inert atmosphere

With sodium azide; sodium hydride; copper(II) sulfate; ascorbic acid; In tetrahydrofuran; water; mineral oil; tert-butyl alcohol;

DOI:10.1002/adsc.201100684

Reference yield:

2-fluoro-dithiobenzoic acid S-methyl ester (114260-11-6) → (4R,5R)-1-benzyl-5-((2-(2-fluorophenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole (1354693-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1: mercury(II) oxide / tetrahydrofuran / 70 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / Inert atmosphere

3: sodium azide; copper(II) sulphate hydrate; ascorbic acid / Inert atmosphere

With sodium azide; copper(II) sulphate hydrate; sodium hydride; mercury(II) oxide; ascorbic acid; In tetrahydrofuran;

DOI:10.1039/c2gc35732a

upstream raw materials:

(4R,5R)-2-(2-fluorophenyl)-4,5-diphenyl-1-(prop-2-yn-1-yl)-4,5-dihydro-1H-imidazole

benzyl bromide

(4R,5R)-2-(2-fluoro-phenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazole

2-fluoro-dithiobenzoic acid S-methyl ester

Downstream raw materials:

1-benzyl-5-(((4R,5R)-2-(2-(diphenyl-phosphino)phenyl)-4,5-diphenyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazole