(E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

Base Information

Chemical Name:(E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide
CAS No.:261705-81-1
Molecular Formula:C₁₇H₁₆N₄O₄
Molecular Weight:340.338
Hs Code.:

Synonyms:(E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

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Chemical Property of (E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

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Technology Process of (E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

There total 4 articles about (E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 15851-92-0,56030-38-7
(E)-3-methoxycinnamoyl chloride

: 146830-75-3
5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 261705-81-1
(E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

Guidance literature:: With pyridine; In ethyl acetate; at 20 ℃; for 16h;
DOI:10.1021/jo0358574

Reference yield: 70.0%

: 6099-04-3,17570-26-2
trans-3-methoxycinnamic acid

: 146830-75-3
5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 261705-81-1
(E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; at 20 ℃; for 4h;
DOI:10.1021/jm9911480

Reference yield:

: 138895-22-4
6-amino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

: 261705-81-1
(E)-N-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / acetic acid; NaNO₂ / H₂O / 65 °C

2: 67 percent / NH₃; sodium dithionite / H₂O / 0.17 h / 70 °C

3: 80 percent / pyridine / ethyl acetate / 16 h / 20 °C

With pyridine; sodium dithionite; ammonia; acetic acid; sodium nitrite; In water; ethyl acetate;
DOI:10.1021/jo0358574