1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-Methyl-1-(4-nitrophenyl)

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-Methyl-1-(4-nitrophenyl)
• CAS No.: 24392-05-0
• Molecular Formula: C₁₁H₈ClN₃O₃
• Molecular Weight: 265.656
• Mol file: 24392-05-0.mol

Synonyms:4-nitrophenyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde

Chemical Property of 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-Methyl-1-(4-nitrophenyl)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-Methyl-1-(4-nitrophenyl)

There total 3 articles about 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-Methyl-1-(4-nitrophenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-(4'-nitrophenyl)-3-methyl-5-pyrazolone (6402-09-1) → 4-nitrophenyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (24392-05-0)

Guidance literature:

With trichlorophosphate;

DOI:10.1016/j.ejmech.2014.08.048

Reference yield:

4-nitrophenylhydrazone (100-16-3) → 4-nitrophenyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (24392-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: trichlorophosphate

With acetic acid; trichlorophosphate; 2: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.ejmech.2014.08.048

Reference yield:

→ 4-nitrophenyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (24392-05-0)

Guidance literature:

1-(4-Nitro-phenyl)-5-oxo-3-methyl-Δ²-pyrazolin, DMF/POCl3, 1. 0grad, 2. Δ;

upstream raw materials:

N,N-dimethyl-formamide

1-(4'-nitrophenyl)-3-methyl-5-pyrazolone

4-nitrophenylhydrazone

Downstream raw materials:

3-methyl-1-(4-nitro-phenyl)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid

3-methyl-1-(4-nitro-phenyl)-1H-thieno[2,3-c]pyrazole