syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

Base Information

Chemical Name:syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine
CAS No.:112317-77-8
Molecular Formula:C₄₁H₄₁N₃O₉
Molecular Weight:719.791
Hs Code.:

syn-N<sup>4</sup>-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

Synonyms:syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

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Technology Process of syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

There total 6 articles about syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 87865-87-0
syn-N⁴-benzoyl-2'-O-(tetrahydrofuran-2-yl)cytidine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 112317-77-8
syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine;
DOI:10.1002/hlca.200790034

Reference yield:

: 98-88-4
benzoyl chloride

: 112317-77-8
syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorotrimethylsilane / pyridine

1.2: pyridine

1.3: 94 percent / NH₄OH

2.1: 94 percent / pyridine

3.1: 97 percent / TsOH / tetrahydrofuran / 3 h / 0 °C

4.1: 41 percent / Bu₄NF / tetrahydrofuran

5.1: 94 percent / iPr₂EtN / pyridine

With chloro-trimethyl-silane; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.200790034

Reference yield:

: 87865-80-3
N⁴-benzoyl-2'-O-(tetrahydrofuran-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

: 112317-77-8
syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / Bu₄NF / tetrahydrofuran

2: 94 percent / iPr₂EtN / pyridine

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.200790034