Multi-step reaction with 7 steps
1.1: hydrogenchloride / 3 h / 63 - 67 °C
2.1: triethylamine / ethyl acetate / 0.5 h / -40 - -12 °C
2.2: 1.5 h / -2 °C
3.1: 2,6-dimethylpyridine / acetonitrile / 0.17 h / -43 - -37 °C
3.2: 0.83 h / -35 °C
3.3: 40 h / -5 - 5 °C
4.1: hydrogenchloride / methanol / 27 h / Reflux
5.1: sodium hydroxide / water; 1,4-dioxane / 1 h / Cooling with ice
5.2: 20 °C
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / Cooling with ice
7.2: 0.08 h / Cooling with ice
7.3: 0.5 h / Cooling with ice
With
2,6-dimethylpyridine; hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetonitrile;