(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol
CAS No.:178422-00-9
Molecular Formula:C₃₁H₃₁N₅O₅
Molecular Weight:553.618
Hs Code.:

Synonyms:(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

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Chemical Property of (2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

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Technology Process of (2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

There total 2 articles about (2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 178421-99-3
[(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine

: 178422-00-9
(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

Guidance literature:: With potassium fluoride; tetraethylammonium bromide; water; In acetonitrile; for 6h; Ambient temperature;
DOI:10.1021/jo952263v

Reference yield:

: 81243-94-9
(2R,3R,3aS,9aR)-5,5,7,7-Tetraisopropyl-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol

: 178422-00-9
(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Ag₂O / 4 h / Heating

2: 97 percent / H₂O, KF, Et₄NBr / acetonitrile / 6 h / Ambient temperature

With potassium fluoride; tetraethylammonium bromide; water; silver(l) oxide; In acetonitrile;
DOI:10.1021/jo952263v

Reference yield:

: 178422-00-9
(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

: 178422-02-1
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / 12 h / Ambient temperature

2: 85 percent / ethyldiisopropylamine / CH₂Cl₂ / 1 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1021/jo952263v