[(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine

Base Information

• Chemical Name: [(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine
• CAS No.: 178421-99-3
• Molecular Formula: C₄₃H₅₇N₅O₆Si₂
• Molecular Weight: 796.126

Synonyms:[(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine

Chemical Property of [(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine

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Technology Process of [(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine

There total 1 articles about [(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2R,3R,3aS,9aR)-5,5,7,7-Tetraisopropyl-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol (81243-94-9) + methyl iodide (74-88-4) → [(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine (178421-99-3)

Guidance literature:

With silver(l) oxide; for 4h; Heating;

DOI:10.1021/jo952263v

Reference yield: 97.0%

[(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine (178421-99-3) → (2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol (178422-00-9)

Guidance literature:

With potassium fluoride; tetraethylammonium bromide; water; In acetonitrile; for 6h; Ambient temperature;

DOI:10.1021/jo952263v

Reference yield:

[(4-Methoxy-phenyl)-diphenyl-methyl]-[9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-amine (178421-99-3) → (2R,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol (178422-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / H₂O, KF, Et₄NBr / acetonitrile / 6 h / Ambient temperature

2: 98 percent / pyridine / 12 h / Ambient temperature

With potassium fluoride; tetraethylammonium bromide; water; In pyridine; acetonitrile;

DOI:10.1021/jo952263v

upstream raw materials:

(2R,3R,3aS,9aR)-5,5,7,7-Tetraisopropyl-2-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol

methyl iodide

Downstream raw materials:

(2R,3R,4R,5R)-2-Hydroxymethyl-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

(2R,3R,4R,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-ol

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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