[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

Base Information

Chemical Name:[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid
CAS No.:1345098-10-3
Molecular Formula:C₁₅H₁₄N₂O₅
Molecular Weight:302.287
Hs Code.:

Synonyms:[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

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Chemical Property of [1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

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Technology Process of [1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

There total 4 articles about [1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345098-09-0
diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

: 1345098-10-3
[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

Guidance literature:: diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate; With water; sodium hydroxide; In 1,4-dioxane; at 45 ℃; for 1.5h;

With hydrogenchloride; In dichloromethane; water; at 10 - 20 ℃; for 1h; pH=1;

Reference yield:

: 1093183-62-0
3-bromo-1-(2,6-dimethyl-4-nitrophenyl)pyridin-2(1H)-one

: 1345098-10-3
[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1,4-dioxane / 1.33 h / 55 - 60 °C / Inert atmosphere

1.2: 8 h / Reflux

2.1: sodium hydroxide; water / 1,4-dioxane / 1.5 h / 45 °C

2.2: 1 h / 10 - 20 °C / pH 1

With potassium tert-butylate; water; sodium hydroxide; In 1,4-dioxane;

Reference yield:

: 142-08-5
2-hydroxypyridin

: 1345098-10-3
[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium bromide; bromine / 3 h / 35 - 40 °C / Large scale

2.1: potassium carbonate / dimethyl sulfoxide / 3.5 h / 120 °C

3.1: potassium tert-butylate / 1,4-dioxane / 1.33 h / 55 - 60 °C / Inert atmosphere

3.2: 8 h / Reflux

4.1: sodium hydroxide; water / 1,4-dioxane / 1.5 h / 45 °C

4.2: 1 h / 10 - 20 °C / pH 1

With potassium tert-butylate; water; bromine; potassium carbonate; potassium bromide; sodium hydroxide; In 1,4-dioxane; dimethyl sulfoxide;