diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

Base Information

Chemical Name:diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate
CAS No.:1345098-09-0
Molecular Formula:C₂₀H₂₂N₂O₇
Molecular Weight:402.404
Hs Code.:

Synonyms:diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

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Chemical Property of diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

Chemical Property:

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Technology Process of diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

There total 3 articles about diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093183-62-0
3-bromo-1-(2,6-dimethyl-4-nitrophenyl)pyridin-2(1H)-one

: 105-53-3
diethyl malonate

: 1345098-09-0
diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

Guidance literature:: diethyl malonate; With potassium tert-butylate; In 1,4-dioxane; at 55 - 60 ℃; for 1.33333h; Inert atmosphere;

3-bromo-1-(2,6-dimethyl-4-nitrophenyl)pyridin-2(1H)-one; With bis(2-pyridinecarboxylato)copper(II)complex; In 1,4-dioxane; for 8h; Reflux;

Reference yield:

: 142-08-5
2-hydroxypyridin

: 1345098-09-0
diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium bromide; bromine / 3 h / 35 - 40 °C / Large scale

2.1: potassium carbonate / dimethyl sulfoxide / 3.5 h / 120 °C

3.1: potassium tert-butylate / 1,4-dioxane / 1.33 h / 55 - 60 °C / Inert atmosphere

3.2: 8 h / Reflux

With potassium tert-butylate; bromine; potassium carbonate; potassium bromide; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 13466-43-8
3-bromopyridin-2(1H)-one

: 1345098-09-0
diethyl[1-(2,6-dimethyl-4-nitrophenyl)-2-oxo-1,2-dihydropyridin-3-yl]malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 3.5 h / 120 °C

2.1: potassium tert-butylate / 1,4-dioxane / 1.33 h / 55 - 60 °C / Inert atmosphere

2.2: 8 h / Reflux

With potassium tert-butylate; potassium carbonate; In 1,4-dioxane; dimethyl sulfoxide;