5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Base Information

• Chemical Name: 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile
• CAS No.: 345922-11-4
• Molecular Formula: C₃₂H₄₀NO₂PSi
• Molecular Weight: 529.734

Synonyms:5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Chemical Property of 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

There total 4 articles about 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

cyanomethylene triphenylphosphorane (16640-68-9) + 3-(tert-butyl-dimethyl-silanyloxy)-hexanoic acid (345922-21-6) → 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-octanenitrile (345922-11-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/jo0015974

Reference yield:

3-hydroxy-hexanoic acid ethyl ester (2305-25-1) → 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-octanenitrile (345922-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: 100 percent / aq. NaOH / methanol / 19 h / 100 °C

3: 57 percent / EDCI; DMAP / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo0015974

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-octanenitrile (345922-11-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: 100 percent / aq. NaOH / methanol / 19 h / 100 °C

3: 57 percent / EDCI; DMAP / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo0015974

upstream raw materials:

cyanomethylene triphenylphosphorane

3-(tert-butyl-dimethyl-silanyloxy)-hexanoic acid

3-hydroxy-hexanoic acid ethyl ester

tert-butyldimethylsilyl chloride

Downstream raw materials:

acetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ⁵-phosphanylidene)-butyl ester

5-hydroxy-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 345922-11-4 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Send

Send

Metric Ton KG G Pound L ML

Send

Send