3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

Base Information

Chemical Name:3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride
CAS No.:1332697-01-4
Molecular Formula:C₂₃H₂₇N₃O₂*ClH
Molecular Weight:413.947
Hs Code.:

Synonyms:3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

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Chemical Property of 3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

Chemical Property:

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Technology Process of 3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

There total 14 articles about 3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1332697-24-1
C₂₈H₃₅N₃O₄

: 1332697-01-4
3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₁H₁₉BrO₇

: 1332697-01-4
3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 12 steps

1: hydrogenchloride; water; acetic acid / 8 h / 120 °C

2: methanol / 15 h / 20 °C

3: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

5: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

6: pyridine; thionyl chloride / tetrahydrofuran; toluene / 3 h / 20 °C

7: ammonia / tetrahydrofuran; ethanol / 5 h / 140 °C / Sealed tube

8: dmap / tetrahydrofuran / 1 h / 20 °C

9: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 15 h / 80 °C

10: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

11: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

12: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 15 h / 20 °C

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; ammonia; water; palladium diacetate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 583837-70-1
6-bromo-1-oxo-4-phenyl-1H-isochromene-3-carboxylic acid

: 1332697-01-4
3-(aminomethyl)-N,N-dimethyl-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-6-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1: methanol / 15 h / 20 °C

2: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

4: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 2 h / 0 °C

5: pyridine; thionyl chloride / tetrahydrofuran; toluene / 3 h / 20 °C

6: ammonia / tetrahydrofuran; ethanol / 5 h / 140 °C / Sealed tube

7: dmap / tetrahydrofuran / 1 h / 20 °C

8: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 15 h / 80 °C

9: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

10: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

11: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 15 h / 20 °C

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; ammonia; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059