methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate
CAS No.:1578268-53-7
Molecular Formula:C₂₉H₂₅FN₂O₃
Molecular Weight:468.528
Hs Code.:

Synonyms:methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

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Chemical Property of methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

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Technology Process of methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

There total 3 articles about methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1217501-08-0
(4-(1-(methoxycarbonyl)cyclopropyl)phenyl)boronic acid

: 1578268-89-9
2‐ethenyl‐N‐(quinolin‐8‐yl)benzamide

: 1578268-53-7
methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

Guidance literature:: With Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; palladium diacetate; Selectfluor; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja412881j

Reference yield:

: 27326-43-8
2-vinylbenzoic acid

: 1578268-53-7
methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: 4-tert-Butylcatechol; Selectfluor; palladium diacetate; Bis(2-ethylhexyl)phosphoric acid; 4,4'-di-tert-butyl-2,2'-bipyridine / water; dichloromethane / 20 °C / Inert atmosphere

With oxalyl dichloride; Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; palladium diacetate; Selectfluor; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja412881j

Reference yield:

: 28269-50-3
2-vinylbenzoic acid chloride

: 1578268-53-7
methyl 1-(4-(2-fluoro-2-(2-(quinolin-8-ylcarbamoyl)phenyl)ethyl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: 4-tert-Butylcatechol; Selectfluor; palladium diacetate; Bis(2-ethylhexyl)phosphoric acid; 4,4'-di-tert-butyl-2,2'-bipyridine / water; dichloromethane / 20 °C / Inert atmosphere

With Bis(2-ethylhexyl)phosphoric acid; 4-tert-Butylcatechol; palladium diacetate; Selectfluor; N-ethyl-N,N-diisopropylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; water;
DOI:10.1021/ja412881j