4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

Base Information

Chemical Name:4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid
CAS No.:233744-18-8
Molecular Formula:C₃₃H₃₉NO₉
Molecular Weight:593.674
Hs Code.:

Synonyms:4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

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Chemical Property of 4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

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Technology Process of 4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

There total 3 articles about 4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-55-4
glutaric anhydride,

: 233744-17-7
[(2R,3R,4S,5R,6S)-5-(4-Amino-benzyloxy)-3,4-bis-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: 233744-18-8
4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

Guidance literature:: In tetrahydrofuran;
DOI:10.1055/s-1999-2779

Reference yield:

: (2R,4aR,6S,7R,8S,8aR)-8-Benzyloxy-6-methoxy-7-(4-nitro-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

: 233744-18-8
4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / BF₃*Et₂O; Me₂NH*BH₃ / CH₂Cl₂ / -20 °C

2: 92 percent / Zn-Cu; acetylacetone / tetrahydrofuran

3: 91 percent / tetrahydrofuran

With dimethylamine borane; boron trifluoride diethyl etherate; copper; acetylacetone; zinc; In tetrahydrofuran; dichloromethane; 1: Ring cleavage / 2: Reduction / 3: Acylation;
DOI:10.1055/s-1999-2779

Reference yield:

: 233744-16-6
[(2R,3R,4S,5R,6S)-3,4-Bis-benzyloxy-6-methoxy-5-(4-nitro-benzyloxy)-tetrahydro-pyran-2-yl]-methanol

: 233744-18-8
4-[4-((2S,3R,4S,5R,6R)-4,5-Bis-benzyloxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenylcarbamoyl]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Zn-Cu; acetylacetone / tetrahydrofuran

2: 91 percent / tetrahydrofuran

With copper; acetylacetone; zinc; In tetrahydrofuran; 1: Reduction / 2: Acylation;
DOI:10.1055/s-1999-2779