6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

Base Information

Chemical Name:6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline
CAS No.:263400-18-6
Molecular Formula:C₂₆H₂₆N₆O₄
Molecular Weight:486.53
Hs Code.:

Synonyms:6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

Suppliers and Price of 6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

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Technology Process of 6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

There total 6 articles about 6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanolic ammonia: methanolic ammonia

: 6-acetoxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline dihydrochloride

: 263400-18-6
6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

Guidance literature:

Reference yield:

: 687995-79-5
acetic acid 7-methoxy-4-{2-methyl-5-[(2-morpholin-4-yl-pyridine-4-carbonyl)-amino]-phenylamino}-quinazolin-6-yl ester

: 263400-18-6
6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

Guidance literature:: With ammonia; In methanol; at 50 ℃;
DOI:10.1016/j.bmcl.2004.08.007

Reference yield:

: 119-32-4
4-Methyl-3-nitroanilin

: 263400-18-6
6-hydroxy-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: Fe; aq. AcOH / 110 °C

3: HCl / propan-2-ol / 85 - 90 °C

4: NH₃ / methanol / 50 °C

With hydrogenchloride; ammonia; iron; acetic acid; triethylamine; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2004.08.007