(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

Base Information

Chemical Name:(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid
CAS No.:135632-29-0
Molecular Formula:C₂₁H₃₀N₂O₅
Molecular Weight:390.48
Hs Code.:

Synonyms:(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

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Chemical Property of (2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

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Technology Process of (2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

There total 9 articles about (2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: 135632-30-3
benzyl (2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionate

: 135632-29-0
(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h; under 760 Torr;
DOI:10.1021/jm00071a009

Reference yield: 90.0%

: 2-benzylidenesuccinic acid 4-<(4-tert-butoxycarbonylamino)-1-piperidide> monoamide

: 135632-29-0
(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

: 2(S)-benzylsuccinic acid 4-<(4-tert-butoxycarbonylamino)-1-piperidide> monoamide

Guidance literature:: With hydrogen; di-μ-chloro-bis(1,5-cyclooctadiene)dirhodium; (2R,4R) (+)-phenyl CAPP; In methanol; at 25 ℃; for 3h; under 750.06 Torr;
DOI:10.1055/s-1994-25511

Reference yield:

: 136159-65-4,96930-27-7
(S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one

: 135632-29-0
(2R)-3-<1-<<4-<(tert-butyloxycarbonyl)amino>piperidinyl>carbonyl>-2-benzyl>propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium hexamethyldisilylamide / 1.) THF, -65 deg C, 45 min, 2.) THF, -70 deg C, 3 h

2: 1.) n-butyllithium / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 3 h

3: 92.5 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

4: oxalyl chloride / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

5: Et₃N / CH₂Cl₂ / 3 h / 0 °C

6: 96.8 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 760 Torr

With n-butyllithium; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a009