N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

Base Information

Chemical Name:N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide
CAS No.:1361398-76-6
Molecular Formula:C₄₄H₅₂N₄O₆
Molecular Weight:732.92
Hs Code.:

N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

Synonyms:N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

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Chemical Property of N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

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Technology Process of N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

There total 12 articles about N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1361398-72-2
2-(5-(benzylamino)pentyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one

: N-(2-(benzyloxy)-5-(oxiran-2-yl)phenyl)formamide

: 1361398-76-6
N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

Guidance literature:: at 120 ℃; for 4h; Neat (no solvent);
DOI:10.1016/j.bmcl.2012.01.013

Reference yield:

: C₁₅H₁₆BrNO₂

: 1361398-76-6
N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride

2: potassium carbonate / tetrahydrofuran; methanol

3: 4 h / 120 °C / Neat (no solvent)

With acetic anhydride; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2012.01.013

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1361398-76-6
N-(5-(2-(benzyl(2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-(benzyloxy)phenyl)formamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 24 h / Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: 3 h / 20 °C

5.1: 4 h / 120 °C / Neat (no solvent)

With aluminum (III) chloride; sodium hydride; hydrazine hydrate; In ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2012.01.013