(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

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Chemical Name:(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide
CAS No.:1373137-85-9
Molecular Formula:C₄₃H₄₈N₈O₄
Molecular Weight:740.905
Hs Code.:

(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

Synonyms:(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

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Chemical Property of (6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

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Technology Process of (6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

There total 11 articles about (6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1251834-08-8
C₃₈H₄₃IN₆O₄

: 1373137-85-9
(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 2h; Reflux;

Reference yield:

: 1144035-86-8
2-(((benzylcarbamoyl)amino)(prop-2-en-1-yl)amino)acetic acid

: 1373137-85-9
(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

1.2: 2 h / 20 °C

2.1: toluene-4-sulfonic acid / toluene / 0.5 h / 80 °C

3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Reflux

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 1074-88-0
1H-indole-7-carbaldehyde

: 1373137-85-9
(6S,9aS)-2-allyl-8-((3-(6-aminopyridin-3-yl)-1-methyl-1H-indol-7-yl)methyl)-N-benzyl-6-(4-(tert-butoxy)benzyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide; iodine / N,N-dimethyl-formamide

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 10 - 20 °C

3.1: acetic acid / methanol / 4 h / 20 °C

3.2: 1 h / 20 °C

4.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4.2: 3 h

5.1: piperidine / dichloromethane

6.1: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

6.2: 2 h / 20 °C

7.1: toluene-4-sulfonic acid / toluene / 0.5 h / 80 °C

8.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Reflux

With piperidine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;