5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide

Base Information

• Chemical Name: 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide
• CAS No.: 1186518-73-9
• Molecular Formula: C₁₀H₁₁ClN₄O₂S
• Molecular Weight: 286.742
• Mol file: 1186518-73-9.mol

Synonyms:5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide

Chemical Property of 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide

There total 5 articles about 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-chloro-N-cyclopropyl-5-(hydroxymethyl)benzenesulfonamide (1186518-72-8) → 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide (1186518-73-9)

Guidance literature:

With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 0 - 20 ℃;

Reference yield:

methyl 4-chloro-3-(N-cyclopropylsulfamoyl)benzoate (1186518-71-7) → 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide (1186518-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

With lithium aluminium tetrahydride; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; toluene;

Reference yield:

methyl 4-chloro-3-(chlorosulfonyl)benzoate (1000933-19-6) → 5-(azidomethyl)-2-chloro-N-cyclopropylbenzenesulfonamide (1186518-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 3 h / 0 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C

With lithium aluminium tetrahydride; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; toluene;

upstream raw materials:

2-chloro-N-cyclopropyl-5-(hydroxymethyl)benzenesulfonamide

methyl 4-chloro-3-(chlorosulfonyl)benzoate

methyl 4-chloro-3-(N-cyclopropylsulfamoyl)benzoate

4-chloro-3-(chlorosulfonyl)benzoic acid

Downstream raw materials:

N-(4-chloro-3-(N-cyclopropylsulfamoyl)benzyl)-4'-methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxamide

Refernces