(5-METHYLPYRIDIN-2-YL)METHANAMINE

Base Information

• Chemical Name: (5-METHYLPYRIDIN-2-YL)METHANAMINE
• CAS No.: 45715-08-0
• Molecular Formula: C7H10 N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• Mol file: 45715-08-0.mol

Synonyms:[(5-Methylpyridin-2-yl)methyl]amine

Chemical Property of (5-METHYLPYRIDIN-2-YL)METHANAMINE

Chemical Property:

• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 215.4°C at 760 mmHg
• PKA: 8.76±0.39(Predicted)
• Flash Point: 104.7°C
• PSA: 38.91000
• Density: 1.027g/cm³
• LogP: 1.54900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(5-Methylpyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-37/38-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-METHYLPYRIDIN-2-YL)METHANAMINE

There total 2 articles about (5-METHYLPYRIDIN-2-YL)METHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methylpicolinonitrile (1620-77-5) → ((5-methyl-pyridin-2-yl)-methyl)-amine (45715-08-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.833333h;

Reference yield:

→ ((5-methyl-pyridin-2-yl)-methyl)-amine (45715-08-0)

Guidance literature:

2-Cyano-5-methylpyridin, LiAlH4;

DOI:10.1039/j39700000688

Reference yield: 87.0%

2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile (448920-98-7) + ((5-methyl-pyridin-2-yl)-methyl)-amine (45715-08-0) → (3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone (208110-64-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; sodium cyanoborohydride; In methanol;

DOI:10.1016/j.saa.2005.01.002

upstream raw materials:

5-methylpicolinonitrile

Downstream raw materials:

(3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone

Refernces

• 1、 -. "PYRROLOPYRAZINE KINASE INHIBITORS". Page/Page column 104; 105. . Retrieved 2013/03/28.