2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

Base Information

Chemical Name:2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite
CAS No.:1572289-19-0
Molecular Formula:C₆₁H₆₆N₁₁O₁₁P
Molecular Weight:1160.24
Hs Code.:

2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

Synonyms:2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

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Chemical Property of 2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

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Technology Process of 2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

There total 7 articles about 2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1609928-34-8
C₅₂H₄₉N₉O₁₀

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1572289-19-0
2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2014.01.024

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 1572289-19-0
2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; dmap / dichloromethane / 48 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / propan-1-ol / 12 h / 100 °C

3: pyridine / 0 - 20 °C

4: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h

5: pyridine / 1 h

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; dmap; triethylamine tris(hydrogen fluoride); triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; propan-1-ol; dichloromethane;
DOI:10.1016/j.bmc.2014.01.024

Reference yield:

: 1609928-35-9
C₄₃H₅₉N₉O₈Si₂

: 1572289-19-0
2′-deoxy-5’-O-(4,4'-dimethoxytrityl)-6-N-{2-[(1,3-diaza-3-methyl-2-oxophenoxazin-9-yl)oxy]ethyl}-2-(phenoxyacetylamino)adenosin-3′-yl 2-cyanoethyl N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h

2: pyridine / 1 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2014.01.024