Technology Process of (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, potassium salt
There total 5 articles about (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, potassium salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
isopropyl alcohol;
at 5 - 50 ℃;
for 5.5h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: chloro-trimethyl-silane; pyridine / dichloromethane / 0.33 h / -12 - -10 °C / Inert atmosphere
1.2: 0.25 h / -12 - -10 °C
2.1: hydrogenchloride / ethyl acetate; water
3.1: potassium hydroxide / isopropyl alcohol / 5.5 h / 5 - 50 °C
With
pyridine; hydrogenchloride; chloro-trimethyl-silane; potassium hydroxide;
In
dichloromethane; water; ethyl acetate; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 1 h / Inert atmosphere
1.2: 16 h
2.1: hydrogenchloride / ethyl acetate; water
3.1: potassium hydroxide / isopropyl alcohol / 5.5 h / 5 - 50 °C
With
hydrogenchloride; potassium hydroxide; N,N,N',N'-tetramethylguanidine;
In
water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
