Technology Process of (3S)-5-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
There total 9 articles about (3S)-5-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
phosphoric acid; sodium carbonate;
In
water;
at 60 ℃;
pH=5;
- Guidance literature:
-
2-Benzyloxy-3-methoxy-zimtsaeure;
With
phenylalanine ammonia lyase-128 from Anabaena variabilis; ammonium carbamate;
In
water;
at 20 - 45 ℃;
for 112h;
Enzymatic reaction;
formaldehyd;
With
sulfuric acid;
In
water;
at 50 ℃;
for 16h;
Solvent;
Catalytic behavior;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate / tetrahydrofuran; toluene / 15 °C / 3750.38 Torr / Inert atmosphere; Large scale
1.2: 12 h / 15 °C / 1500.15 Torr / Large scale
2.1: lithium hydroxide; water / tetrahydrofuran / 1 h / 17 °C / Large scale
3.1: hydrogenchloride / ethyl acetate / 2 h / 10 °C / Large scale
4.1: sodium carbonate; phosphoric acid / water / 60 °C / pH 5
With
hydrogenchloride; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; phosphoric acid; water; sodium carbonate; lithium hydroxide;
In
tetrahydrofuran; water; ethyl acetate; toluene;
