N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

Base Information

Chemical Name:N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide
CAS No.:1416739-71-3
Molecular Formula:C₂₂H₂₀N₄O₃S
Molecular Weight:420.492
Hs Code.:

Synonyms:N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

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Technology Process of N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

There total 11 articles about N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1416740-14-1
N-(2-(4-(isopropylsulfonyl)phenyl)-5-tosyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

: 1416739-71-3
N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1349151-81-0
5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1416739-71-3
N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

4.1: water; sodium carbonate / methanol / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5.2: 0.5 h

6.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 1.5 h / 80 °C

7.1: pyridine; Iodine monochloride / dichloromethane / 21.5 h / 0 - 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

8.2: 16 h / 0 - 20 °C

8.3: 0.33 h

9.1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / 1,4-dioxane / 1 h / 95 °C

10.1: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With pyridine; dmap; potassium phosphate; N-Bromosuccinimide; potassium tert-butylate; water; Iodine monochloride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; lithium hydroxide; N,N`-dimethylethylenediamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350351-04-0
3-ethynyl-5-(4-(isopropylsulfonyl)phenyl)pyrazin-2-amine

: 1416739-71-3
N-(2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 1.5 h / 80 °C

2.1: pyridine; Iodine monochloride / dichloromethane / 21.5 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 16 h / 0 - 20 °C

3.3: 0.33 h

4.1: potassium phosphate; N,N`-dimethylethylenediamine / copper(l) iodide / 1,4-dioxane / 1 h / 95 °C

5.1: lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

With pyridine; potassium phosphate; potassium tert-butylate; Iodine monochloride; sodium hydride; lithium hydroxide; N,N`-dimethylethylenediamine; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; mineral oil;