C₃₆H₅₄O₇Si

Base Information

• Chemical Name: C₃₆H₅₄O₇Si
• CAS No.: 219780-53-7
• Molecular Formula: C₃₆H₅₄O₇Si
• Molecular Weight: 626.906
• Mol file: 219780-53-7.mol

Synonyms:C₃₆H₅₄O₇Si

Chemical Property of C₃₆H₅₄O₇Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₅₄O₇Si

There total 33 articles about C₃₆H₅₄O₇Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Methoxypropene (116-11-0) + C32H46O6Si (219780-86-6) → C36H54O7Si (219780-53-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1021/ja9939439

Reference yield:

C39H62O6Si2 (219780-47-9) → C36H54O7Si (219780-53-7)

Guidance literature:

Multi-step reaction with 14 steps

1.1: 66 percent / diethyl zinc / toluene; hexane / 0.5 h / 0 °C

2.1: 77 percent / Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

3.1: 84 percent / H₂ / Pd(OH)2 / ethanol / 0.5 h / 20 °C

4.1: pyridine / CH₂Cl₂ / 2 h / -45 °C

5.1: 0.742 g / TBAF; AcOH / tetrahydrofuran / 2.5 h / 20 °C

6.1: 86 percent / pyridinium p-toluenesulfonate / benzene / 1 h / Heating

7.1: 100 percent / K₂CO₃ / tetrahydrofuran; methanol / 1 h / 20 °C

8.1: 100 percent / SmI₂; methanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 5 h / 20 °C

9.1: TBAF; 2,6-di-t-butyl-4-hydroxytoluene / tetrahydrofuran / 3 h / 20 °C

9.2: 45 percent / sodium methoxide / methanol; tetrahydrofuran / 60 h / 20 °C

10.1: pyridine / CH₂Cl₂ / 0.25 h / 20 °C

11.1: 2,6-lutidine / CH₂Cl₂ / 12 h / -45 °C

12.1: 6.6 mg / aq. hydrogen peroxide; aq. Na₂CO₃ / ethyl acetate / 1 h / 20 °C

13.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

14.1: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.08 h / 20 °C

With pyridine; 2,6-dimethylpyridine; methanol; samarium diiodide; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; diethylzinc; 2,6-di-tert-butyl-4-hydroxytoluene; pyridinium p-toluenesulfonate; sodium carbonate; potassium carbonate; Dess-Martin periodane; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; ethyl acetate; toluene; benzene; 1.1: Cycloaddition / 2.1: Dess-Martin oxidation / 3.1: Hydrogenolysis / 4.1: cyclocondensation / 5.1: desilylation / 6.1: cyclocondensation / 7.1: Ring cleavage / 8.1: Ring cleavage / 9.1: desilylation / 9.2: Isomerization / 10.1: cyclocondensation / 11.1: silylation / 12.1: Ring cleavage / 13.1: Dess-Martin oxidation / 14.1: Addition;

DOI:10.1021/ja9939439

Reference yield:

C40H62O6Si2 (219780-48-0) → C36H54O7Si (219780-53-7)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 84 percent / H₂ / Pd(OH)2 / ethanol / 0.5 h / 20 °C

2.1: pyridine / CH₂Cl₂ / 2 h / -45 °C

3.1: 0.742 g / TBAF; AcOH / tetrahydrofuran / 2.5 h / 20 °C

4.1: 86 percent / pyridinium p-toluenesulfonate / benzene / 1 h / Heating

5.1: 100 percent / K₂CO₃ / tetrahydrofuran; methanol / 1 h / 20 °C

6.1: 100 percent / SmI₂; methanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 5 h / 20 °C

7.1: TBAF; 2,6-di-t-butyl-4-hydroxytoluene / tetrahydrofuran / 3 h / 20 °C

7.2: 45 percent / sodium methoxide / methanol; tetrahydrofuran / 60 h / 20 °C

8.1: pyridine / CH₂Cl₂ / 0.25 h / 20 °C

9.1: 2,6-lutidine / CH₂Cl₂ / 12 h / -45 °C

10.1: 6.6 mg / aq. hydrogen peroxide; aq. Na₂CO₃ / ethyl acetate / 1 h / 20 °C

11.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

12.1: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.08 h / 20 °C

With pyridine; 2,6-dimethylpyridine; methanol; samarium diiodide; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; 2,6-di-tert-butyl-4-hydroxytoluene; pyridinium p-toluenesulfonate; sodium carbonate; potassium carbonate; Dess-Martin periodane; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; ethyl acetate; benzene; 1.1: Hydrogenolysis / 2.1: cyclocondensation / 3.1: desilylation / 4.1: cyclocondensation / 5.1: Ring cleavage / 6.1: Ring cleavage / 7.1: desilylation / 7.2: Isomerization / 8.1: cyclocondensation / 9.1: silylation / 10.1: Ring cleavage / 11.1: Dess-Martin oxidation / 12.1: Addition;

DOI:10.1021/ja9939439

upstream raw materials:

2-Methoxypropene

C₃₂H₄₆O₆Si

C₄₆H₆₆O₈Si₂

t-butyldimethylsiyl triflate

Downstream raw materials:

C₃₇H₅₃F₃O₉SSi

7-(2,2,2-trichloroethyloxycarbonyl)baccatin III

taxol

C₃₇H₅₅ClO₆Si